Metascreen is a highly accurate and specific newborn screening test as it combines the following systems to detect metabolic disorders:

Gas Chromatography-Mass Spectrometry (GC/MS)

  • FDA approved method for urinary detection of chemical substance (“analyte”)
  • Gold standard for lipids, drug metabolites and environmental analysis;
  • Detects more than 250 compounds for the screening of over 100 inborn errors of metabolism (“IEMs”) from urine;
  • Chromatography separates potentially interfering compounds, such as drugs, also excreted in the urine, so the integrity of the test result is intact.

Planar Bioinformatics

  • Uses multiple analyte profiles to detect one single metabolic disorder to ensure high level of specificity of test result;
  • Benchmarked against international and local database of normal samples for the identification of an abnormal case.
Metabolic Disorder Analyte Profiles used with GC/MS Analyte Profiles used with other technology (e.g MS/MS)
Phenylketonuria (PKU)
  1. Phenylalanine
  2. Phenyllactic acid
  3. Phenylpyruvic acid
  4. 2-hydroxyphenylacetic acid
  1. Phenylalanine
Maple Syrup Urine Disease(MSUD)
  1. Leucine
  2. Valine
  3. Isoleucine
  4. 2-hydroxyisocaproic acid
  5. 2-hydroxyisovaleric acid
  6. 2-hydroxy-3-methyvaleric acid
  1. Leucine
  2. Valine
Isovaleric acidemia (IVA)
  1. 3-hydroxyisovaleric acid
  2. Isovaleryl glycine
  1. Isovaleryl carnitine